解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3613
更新日期:2015-10-01 00:00:00
abstract::The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3615
更新日期:2015-10-01 00:00:00
abstract::Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3511
更新日期:2015-10-01 00:00:00
abstract::The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3519
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3607
更新日期:2015-10-01 00:00:00
abstract::The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3579
更新日期:2015-10-01 00:00:00
abstract::The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3547
更新日期:2015-10-01 00:00:00
abstract::The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3515
更新日期:2015-10-01 00:00:00
abstract::The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as signi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3553
更新日期:2015-10-01 00:00:00
abstract::The present study reports a case of hemorrhage from branches of the right obturator artery following laparoscopic radical prostatectomy. On post-operative day 9, the patient complained of lower abdominal pain, and the hemoglobin and hematocrit levels had decreased. Emergency computed tomography angiography showed a la...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3381
更新日期:2015-09-01 00:00:00
abstract::The anticancer effect of Scutellaria baicalensis extract has recently become a topic of interest. In this study, the anticancer effects and underlying mechanisms of wogonoside, the main constituent of Scutellaria baicalensis, were investigated in a human hepatocellular carcinoma (HCC) cell line in vitro. The effects o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3408
更新日期:2015-09-01 00:00:00
abstract::The present study aimed to investigate the clinical characteristics, diagnosis and treatment of accessory breast cancer, and contribute valuable information regarding this rare tumour to the current literature, ultimately facilitating the development of improved treatment strategies. The present study reported the cas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3388
更新日期:2015-09-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90-95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3495
更新日期:2015-09-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide. In the present study, a prostate SFT case, which was initially misdiagnosed as benign pros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3379
更新日期:2015-09-01 00:00:00
abstract::Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3422
更新日期:2015-09-01 00:00:00
abstract::Fibroadenomas are a type of benign tumor that occur in young women below the age of 35 years old. The tumors are the second most common type of tumor after fibrocystic disease. The chance of carcinoma arising in a fibroadenoma is extremely low. To date, <130 such cases have been reported. Previous studies have reporte...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3420
更新日期:2015-09-01 00:00:00
abstract::Survivin is expressed in the nucleus and/or cytoplasm of various malignant cells. Nuclear survivin is critical for the completion of mitosis, while cytoplasmic survivin functions as an inhibitor of apoptosis. The expression of survivin has been reported to be associated with the aggressiveness of certain types of canc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3374
更新日期:2015-09-01 00:00:00
abstract::Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3488
更新日期:2015-09-01 00:00:00
abstract::The chemokine system has been reported to be utilized and manipulated by tumor cells in order to promote local tumor growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in lung carcinoma tissues. Tumor and healthy normal tissue samples were ob...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3402
更新日期:2015-09-01 00:00:00
abstract::The aim of the present study was to evaluate the expression of peroxisome proliferator-activated receptor (PPAR)-γ in inflammatory bowel disease (IBD), and to also identify the association between PPAR-γ and the clinical features of patients with IBD. An azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3397
更新日期:2015-09-01 00:00:00
abstract::Distant metastases from colorectal cancer (CRC) most frequently spread to the liver and lungs. CRC metastasis to the kidney is extremely rare and may be generally associated with an unfavorable prognosis. Thus, patients with metastatic CRC and kidney metastasis are a diagnostic and therapeutic challenge. The present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3290
更新日期:2015-08-01 00:00:00
abstract::Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3311
更新日期:2015-08-01 00:00:00
abstract::The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3279
更新日期:2015-08-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT. EMT occurred i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3287
更新日期:2015-08-01 00:00:00
abstract::The aim of the present study was to investigate the effects of the heat shock protein (HSP)90 inhibitor AUY922 on the proliferation and migratory ability of renal cell carcinoma (RCC) cells. The expression of HSP90 was measured in vitro using western blotting and quantitative polymerase chain reaction in the ACHN and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3299
更新日期:2015-08-01 00:00:00
abstract::With the continuous advancement of clinical diagnostic techniques, including imaging technology, the incidence of confirmed multiple primary cancers or double primary carcinoma increases yearly. However, studies reporting synchronization surgery performed for primary dual esophageal gastric cancer are rare. The presen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3301
更新日期:2015-08-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the si...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3323
更新日期:2015-08-01 00:00:00
abstract::The aim of the present study was to investigate the immunohistochemical expression of cluster of differentiation (CD) 34 and vascular endothelial growth factor (VEGF) in breast cancer tissue, and their prognostic significance. High CD34 expression levels (microvessel density, >15/HPF) were identified in 27.3% (12/44) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3348
更新日期:2015-08-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3306
更新日期:2015-08-01 00:00:00
abstract::Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce imm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3295
更新日期:2015-08-01 00:00:00
abstract::The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restrictio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3154
更新日期:2015-07-01 00:00:00
abstract::The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3202
更新日期:2015-07-01 00:00:00
abstract::Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3193
更新日期:2015-07-01 00:00:00
abstract::The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3240
更新日期:2015-07-01 00:00:00
abstract::Pulmonary benign metastasizing leiomyoma (BML) is a rare event characterized by benign soft-tissue tumors that occur when uterine leiomyomas metastasize to the lung. The present study reports the case of a 47-year-old female patient who presented with multiple bilateral pulmonary nodules on a chest X-ray during a heal...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3224
更新日期:2015-07-01 00:00:00
abstract::Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3157
更新日期:2015-07-01 00:00:00
abstract::The present study reported three rare cases of multicystic vestibular schwannoma with fluid-fluid levels. These three tumors exhibited apparent fluid-fluid levels that demonstrated a radiological appearance of two fluid levels in the cystic area. Two cases had an acute history, whereas one case presented with a chroni...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3211
更新日期:2015-07-01 00:00:00